Immunopathology of bullous pemphigoid, an autoimmune and inflammatory skin blistering disease.

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The immunopathology of pemphigus and bullous pemphigoid.

This review article was prepared for the Journal of Investigative Dermatology by invitation. It is the first of a series of such articles which will appear in this journal in the months to come. Doctor Richard Winkelmann has taken on the responsibilities of obtaining and organizing these reviews. The Society for Investigative Dermatology is deeply grateful for his efforts and is particularly in...

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W. Nishie , M.D., Ph.D. • H. Shimizu , M.D., Ph.D. (*) Department of Dermatology , Hokkaido University Graduate School of Medicine , N15W7, Kita-ku , Sapporo 003-0835 , Japan e-mail: [email protected] Abstract Bullous pemphigoid (BP) is the most common autoimmune blistering disorder. BP autoantibodies target two hemidesmosomal components, collagen XVII (COL17) and BP230, with autoimmuni...

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The Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury

Bullous pemphigoid (BP) is an autoimmune and inflammatory skin disease associated with subepidermal blistering and autoantibodies directed against the hemidesmosomal components BP180 and BP230. Animal models of BP were developed by passively transferring anti-BP180 IgG into mice, which recapitulates the key features of human BP. By using these in vivo model systems, key cellular and molecular e...

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Pemphigoid pdf

Pemphigoid diseases are a group of well defined autoimmune disorders. The most common of these diseases is bullous pemphigoid, which. Abstract Bullous pemphigoid BP is a blistering skin disease. Plex and includes bullous pemphigoid, pemphigoid gestationis, mucous.Bullous pemphigoid BP is an autoimmune subepidermal bullous dermatosis defined. Http:www.orpha.netdatapathoGBukBullousPemphigoid.pdf....

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Immunopathology and molecular diagnosis of autoimmune bullous diseases

Autoimmune bullous diseases are associated with autoimmunity against structural components maintaining cell-cell and cell matrix adhesion in the skin and mucous membranes. Pemphigus diseases are characterized by autoantibodies against the intercellular junctions and intraepithelial blisters. In pemphigoid diseases and epidermolysis bullosa acquisita, sub-epidermal blistering is associated with ...

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ژورنال

عنوان ژورنال: The Keio Journal of Medicine

سال: 2003

ISSN: 1880-1293,0022-9717

DOI: 10.2302/kjm.52.128